Acetic Acid → 2-(4-Phenoxymethylphenoxy)-propionic acid

HRID 441418Notes

Reaction equation

HRID 441418 reaction equation
[O:1]([CH2:8][C:9]1[CH:20]=[CH:19][C:12]([O:13][CH:14]([CH3:18])[C:15](N)=[O:16])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.C(O)(=[O:24])C>O>[O:1]([CH2:8][C:9]1[CH:20]=[CH:19][C:12]([O:13][CH:14]([CH3:18])[C:15]([OH:24])=[O:16])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 214211722-(4-Phenoxymethylphenoxy)-propionamide

Product 1

HCID 214211732-(4-Phenoxymethylphenoxy)-propionic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1 g. of 2-(4-phenoxymethylphenoxy)-propionamide, 2 ml. of concentrated hydrochlorid acid, and 2 ml. of acetic acid is refluxed for 48 hours and, after adding water, worked up as usual, yielding 2-(4-phenoxymethylphenoxy)-propionic acid.

Workup

  1. additionA mixture of 1 g

Sources & evidence

ORD record
ord-0f51d2afa2554271ac590ad40ead67ab
Source dataset
uspto-grants-1977_08
Patent number
US04039683

Reaction notes

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