反应详情

To 250 ml of isopropyl alcohol is added one equivalent of 9-ethylcarbazole-3,6-dicarboxylic acid, 2 equivalents of 3-piperidinopropylchloride, and a catalytic amount of benzyltrimethylammonium chloride. The mixture is heated to reflux for 2 hours. Upon cooling a solid forms which is collected, washed with ether, dried and dissolved in water. The aqueous solution is made basic with saturated sodium bicarbonate, and the product is extracted with ether. The ether solution is washed with water, dried, and acidified with ethereal HCl. The resulting precipitate is recrystallized from methanol-butanone to give bis(3-piperidinopropyl)-9-ethylcarbazole-3,6-dicarboxylate dihydrochloride.

1. temperatureThe mixture is heated
2. temperatureto reflux for 2 hours
3. temperatureUpon cooling a solid forms which
4. customis collected
5. washwashed with ether
6. customdried
7. dissolutiondissolved in water
8. extractionthe product is extracted with ether
9. washThe ether solution is washed with water
10. customdried
11. customThe resulting precipitate is recrystallized from methanol-butanone