反应详情

To a solution of 6-bromo-3,4-dihydro-1H-quinolin-2-one (339 mg, 1.50 mmol) in 15 ml dry DMF was added potassium tert-butylate (336 mg, 3.0 mmol). After the mixture was stirred for 30 min at room temperature, a solution of methyl iodide (426 mg, 3.0 mmol) in 5 ml dry DMF was added. Following overnight stirring, the mixture was diluted with 100 ml 1 N HCl. Extraction with ethyl acetate (2×100 mL) followed by washing of the organic extracts with water and brine, drying over MgSO4 and removal of the solvent in vacuo gave a light yellow solid. Purification by flash chromatography (hexanes/ethyl acetate, 7/3, Rf=0.21) gave 6-bromo-1-methyl-3,4-dihydro-1H-quinolin-2-one (281 mg, 1.17 mmol, 78%) as colorless needles.

1. waitFollowing overnight
2. stirringstirring
3. extractionExtraction with ethyl acetate (2×100 mL)
4. washby washing of the organic extracts with water and brine
5. dry with materialdrying over MgSO4 and removal of the solvent in vacuo
6. customgave a light yellow solid
7. customPurification by flash chromatography (hexanes/ethyl acetate, 7/3, Rf=0.21)