Methanol → 2-Amino-5-bromo-3-methoxypyrazine

HRID 441743Notes

Reaction equation

HRID 441743 reaction equation

[NH2:1][C:2]1[C:7](Br)=[N:6][C:5]([Br:9])=[CH:4][N:3]=1.[Na].[CH3:11][OH:12]>>[NH2:1][C:2]1[C:7]([O:12][CH3:11])=[N:6][C:5]([Br:9])=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 887Methanol

HCID 6200042-Amino-3,5-dibromopyrazine

HCID 5360545Sodium

Product 1

HCID 113447242-Amino-5-bromo-3-methoxypyrazine

Procedure

2-Amino-3,5-dibromopyrazine (7 g.) is boiled for about 9 hours with 0.65 g. sodium in 18.5 ml. methanol to give 2-amino-3-methoxy-5-bromopyrazine.

Sources & evidence

ORD record: ord-f304e8276e06497bab8cbd05771bd48c
Source dataset: uspto-grants-1977_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04042586

Reaction notes

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