Benzyl Bromide → HCID 21418170, compound

HRID 441812Notes

Reaction equation

HRID 441812 reaction equation
C(=O)([O-])[O-].[Na+].[Na+].[CH2:7]([Br:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[Br-].[OH:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[CH:23]=[N+:22]([CH3:27])[CH:21]=[CH:20]2>C(#N)C>[Br-:14].[CH2:7]([O:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[CH:23]=[N+:22]([CH3:27])[CH:21]=[CH:20]2)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 10340Sodium CarbonateHCID 21418186HCID 21418186, compound

Product 1

HCID 21418170HCID 21418170, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Sodium carbonate (5 g.), benzyl bromide (2 ml), 6-hydroxy-2-methylisoquinolinium bromide (2.5 g.) in acetonitrile (100 ml) were heated under reflux for 2 hr. The suspension was filtered hot and the filtrate was diluted with ether. The solid that precipitated was crystallised from acetonitrile, and had m.p. 210°-213°.

Workup

  1. temperatureunder reflux for 2 hr
  2. filtrationThe suspension was filtered hot
  3. additionthe filtrate was diluted with ether
  4. customThe solid that precipitated
  5. customwas crystallised from acetonitrile

Sources & evidence

ORD record
ord-0f3d04ae7a9e4d89890c90b6965e4963
Source dataset
uspto-grants-1977_08
Patent number
US04042697

Reaction notes

Loading…