反应详情

To a solution of (2-amino-5-bromophenyl)methanol (772 mg, 3.8 mmol) in 15 ml THF was added triphosgene (1.03 g, 3.8 mmol) under nitrogen. After precipitation of a colorless solid, stirring was continued for 20 min before water was added. The solution was extracted several times with ethyl acetate. The combined organic layers were washed with brine, dried over MgSO4 and evaporated, affording 6-bromo-1H-benzo[d][1,3]oxazin-2(4H)-one (830 mg, 3.64 mmol, 96%) as colorless solid.

1. customAfter precipitation of a colorless solid
2. additionwas added
3. extractionThe solution was extracted several times with ethyl acetate
4. washThe combined organic layers were washed with brine
5. dry with materialdried over MgSO4
6. customevaporated