Hydrochloric Acid → HCID 12232370, compound

HRID 441983Notes

Reaction equation

HRID 441983 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]2[S:6][C:7]3[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:8]=3[CH:9](O)[CH2:10][C:4]=2[CH:3]=1.[Cl-:19].[Ca+2].[Cl-].Cl>C1C=CC=CC=1>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]2[S:6][C:7]3[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:8]=3[CH:9]([Cl:19])[CH2:10][C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 5284359Calcium ChlorideHCID 12232365HCID 12232365, compound

Product 1

HCID 12232370HCID 12232370, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

58.3 G. of 2-chloro-8-fluoro-10,11-dihydro-dibenzo[b,f]thiepin-10-ol 300 ml. of benzene and 21 g. of finely pulverized calcium chloride are saturated with hydrochloric acid over a period of 2 hours at 15°. The resulting precipitate is filtered, washed with benzene and evaporated under reduced pressure, whereby there is obtained 2,10-dichloro-8-fluoro-10,11-dihydro-dibenzo[b,f]thiepin as white crystals, having a melting point of 84°-85°.

Workup

  1. filtrationThe resulting precipitate is filtered
  2. washwashed with benzene
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-ce1b5ff83e5347e28f6a20493b390925
Source dataset
uspto-grants-1977_08
Patent number
US04044010

Reaction notes

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