Ethanol → HCID 86735020, compound

HRID 442170Notes

Reaction equation

HRID 442170 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:32]=[CH:33][CH:34]=1)[CH2:5][O:6][C:7]([C:9]1C(C2C=CC=C([N+]([O-])=O)C=2)C(C(OC(C)C)=O)=C(C)[NH:13][C:14]=1[CH3:15])=[O:8].C(O)C>C(O)(C)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:32]=[CH:33][CH:34]=1)[CH2:5][O:6][C:7](=[O:8])/[CH:9]=[C:14](\[NH2:13])/[CH3:15]

Participants

4

Reactant 2

HCID 702EthanolHCID 68121812HCID 68121812, compound

Product 1

HCID 86735020HCID 86735020, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 3'-nitrobenzylideneacetoaceic acid isopropyl ester and 75 mmols of β-aminocrotonic acid 3-chlorobenzyl ester in 120 ml of isopropanol gave 2,6-dimethyl-3-isopropoxycarbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 3-chlorobenzyl ester of melting point 104° C (from ethanol).

Sources & evidence

ORD record
ord-5d779034f35a42e485c80560e99af49c
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

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