反应详情

A mixture of 3-fluoro-6-nitrobenzaldehyde (10.0 g., 0.0592 mole), 2-cyanoacetamide (5.24 g., 0.0622 mole), piperidine (0.37 g., 4.36 millimole) and ethanol (92 ml.) is heated to reflux on a steam bath for two hours. It is then cooled in an ice-bath whereupon the product precipitates and is recovered by filtration, washed with cold ethanol and dried. Yield = 9.1 g. (65%) of crude product. M.P. 162°-166° C.

1. temperatureis heated
2. temperatureto reflux on a steam bath for two hours
3. temperatureIt is then cooled in an ice-bath whereupon the product
4. customprecipitates
5. filtrationis recovered by filtration
6. washwashed with cold ethanol
7. customdried