Methanol → HCID 70636376, compound

HRID 442231Notes

Reaction equation

HRID 442231 reaction equation
C[O-].[Na+].[Na:4].CO.[OH:7][CH:8]([C:20]1[CH:30]=[CH:29][C:23]([NH:24][S:25]([CH3:28])(=[O:27])=[O:26])=[CH:22][CH:21]=1)[CH2:9][NH:10][CH2:11][CH2:12][O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CCOCC>[Na:4].[OH:7][CH:8]([C:20]1[CH:21]=[CH:22][C:23]([NH:24][S:25]([CH3:28])(=[O:27])=[O:26])=[CH:29][CH:30]=1)[CH2:9][NH:10][CH2:11][CH2:12][O:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

6

Reactant 4

HCID 887Methanol2×HCID 5360545SodiumHCID 10942334Sodium MethoxideHCID 21416900HCID 21416900, compound

Product 1

HCID 70636376HCID 70636376, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of sodium methoxide prepared from sodium (0.23 g., 0.01 gram atom) and 15 ml. of methanol is mixed with a solution of 4'-[1-hydroxy-2-[(2-phenoxyethyl)amino]ethyl]methanesulfonanilide (3.5 g., 0.01 mole) in 50 ml. of methanol. Anhydrous ether is added to precipitate the sodium salt or the methanolic solution is concentrated under reduced pressure to provide 4'-[1-hydroxy-2-[(2-phenoxyethyl)amino]ethyl]methanesulfonanilide sodium salt.

Workup

  1. customto precipitate the sodium salt
  2. concentrationthe methanolic solution is concentrated under reduced pressure

Sources & evidence

ORD record
ord-1f7f1a1779b64774add1c44aa2c49da5
Source dataset
uspto-grants-1977_08
Patent number
US04044150

Reaction notes

Loading…