Hydroxyamine hydrochloride → HCID 136354598, compound

HRID 442240Notes

Reaction equation

HRID 442240 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:8]=[C:5]([CH:6]=O)[C:4]=1[OH:15].Cl.[NH2:19][OH:20].C([O-])(=O)C.[Na+]>C(O)C.O>[F:1][C:2]([F:17])([F:16])[C:3]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:8]=[C:5]([CH:6]=[N:19][OH:20])[C:4]=1[OH:15]

Participants

6

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 198618175-tert-Butyl-2-hydroxy-3-(trifluoromethyl)benzaldehyde

Product 1

HCID 136354598HCID 136354598, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent2×

Procedure

0.05 moles of the aldehyde from Step A, 0.12 moles of hydroxylamine hydrochloride and sodium acetate (0.12 moles) are dissolved in a mixture of ethanol (100 ml.) and water (30 ml.). The reaction mixture is refluxed for 2 hours, cooled and water added until no more precipitate forms. The solid that separates is crystallized from ethanol to yield 3-trifluoromethyl-5-tert-butyl salicylaldehyde oxime.

Workup

  1. temperatureThe reaction mixture is refluxed for 2 hours
  2. temperaturecooled
  3. customThe solid that separates is crystallized from ethanol

Sources & evidence

ORD record
ord-5647840ada274f32bafe82475b2906f3
Source dataset
uspto-grants-1977_08
Patent number
US04044153

Reaction notes

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