反应详情

A mixture of 2-acetoxy-5-(4'-fluoro-2'-methoxyphenyl)-benzoic acid (0.1 mole), phosphorous oxychloride (0.1 mole), and phenol (0.12 mole), is heated at 75° C. until no more hydrogen chloride is evolved. The product, phenyl-2-acetoxy-5-(4'-fluoro-2'-methoxyphenyl)-benzoate, is isolated by partitioning the reaction mixture between benzene and dilute sodium bicarbonate solution, and subjecting the benzene solution to chromatography on silica gel.