Hydrochloric Acid → HCID 21416424, compound

HRID 442272Notes

Reaction equation

HRID 442272 reaction equation
[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[O:21][CH3:22])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2].P(Cl)(Cl)(Cl)=O.[C:28]1(O)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.Cl>>[C:28]1([O:8][C:7](=[O:9])[C:6]2[CH:10]=[C:11]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[O:21][CH3:22])[CH:12]=[CH:13][C:5]=2[O:4][C:1](=[O:3])[CH3:2])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 996PhenolHCID 24813Phosphorus oxychlorideHCID 21416425HCID 21416425, compound

Product 1

HCID 21416424HCID 21416424, compound

Procedure

A mixture of 2-acetoxy-5-(4'-fluoro-2'-methoxyphenyl)-benzoic acid (0.1 mole), phosphorous oxychloride (0.1 mole), and phenol (0.12 mole), is heated at 75° C. until no more hydrogen chloride is evolved. The product, phenyl-2-acetoxy-5-(4'-fluoro-2'-methoxyphenyl)-benzoate, is isolated by partitioning the reaction mixture between benzene and dilute sodium bicarbonate solution, and subjecting the benzene solution to chromatography on silica gel.

Sources & evidence

ORD record
ord-80a9fdd6b34d4e28b59dd401322e7d54
Source dataset
uspto-grants-1977_08
Patent number
US04044049

Reaction notes

Loading…