3,4-Dichlorophenyl isocyanate → HCID 21414076, compound

HRID 442282Notes

Reaction equation

HRID 442282 reaction equation
[C:1]([S:5][NH:6][CH3:7])([CH3:4])([CH3:3])[CH3:2].[Cl:8][C:9]1[CH:10]=[C:11]([N:16]=[C:17]=[O:18])[CH:12]=[CH:13][C:14]=1[Cl:15]>C(N(CC)CC)C.O1CCCC1>[CH3:7][N:6]([S:5][C:1]([CH3:4])([CH3:3])[CH3:2])[C:17]([NH:16][C:11]1[CH:12]=[CH:13][C:14]([Cl:15])=[C:9]([Cl:8])[CH:10]=1)=[O:18]

Participants

5

Reactant 2

HCID 76073,4-Dichlorophenyl isocyanateHCID 86735038HCID 86735038, compound

Product 1

HCID 21414076HCID 21414076, compoundYield 82.8%

Reagents, catalysts & solvents 2

HCID 8471TriethylamineCatalystHCID 8028TetrahydrofuranSolvent

Procedure

12 g of tert.-butylmercapto monomethylamine, 20 g of 3,4-dichlorophenyl isocyanate and 3 drops of triethylamine were added to 120 ml of tetrahydrofuran and after stirring the mixture for 30 minutes, the solvent was distilled off under reduced pressure. The residue was crystallized from ethanol to obtain 25.6 g of N-methyl-N-tert.-butylthio-N'-(3,4-dichlorophenyl)-urea melting at 127° C.

Workup

  1. distillationthe solvent was distilled off under reduced pressure
  2. customThe residue was crystallized from ethanol

Sources & evidence

ORD record
ord-9dc5a5311e3e4c88a0600c4042a38316
Source dataset
uspto-grants-1977_08
Patent number
US04045209

Reaction notes

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