Water → HCID 21415009, compound

HRID 442518Notes

Reaction equation

HRID 442518 reaction equation
[CH2:1]([N:8]1[C:13](=O)[CH2:12][O:11][CH:10]([CH2:15][C:16]23[CH2:31][CH2:30][CH:23]([C:24]4[CH:25]=[CH:26][CH:27]=[CH:28][C:29]=42)[C:22]2[C:17]3=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCOCC1.C(OCC)(=O)C>[CH2:1]([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:15][C:16]23[CH2:31][CH2:30][CH:23]([C:22]4[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=42)[C:24]2[C:29]3=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 3

HCID 962WaterHCID 21226445Aluminium lithium hydride2×HCID 21414999HCID 21414999, compound

Product 1

HCID 21415009HCID 21415009, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

A mixture of 9-(4-benzyl-5-oxo-2-morpholinylmethyl)-9,10-dihydro-9,10-ethanoanthracene (1.07 g) and lithium aluminum hydride (400 mg) in dioxane was stirred at 50° -60° C. for 2 hours. Excess lithium aluminum hydride was decomposed by addition of water. The reaction mixture was diluted with ethyl acetate, dried over anhydrous sodium sulfate and evaporated to dryness to give 9-(4-benzyl-2-morpholinylmethyl)-9,10-dihydro-9,10-ethanoanthracene, I.R., 3060, 3010, 2860, 2800, 1215, 1139, 1099, 1030, 980, 698, 660 cm-1.

Workup

  1. dry with materialdried over anhydrous sodium sulfate
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-7e80fdf4a3534afa8cc5a982d3be2fda
Source dataset
uspto-grants-1977_08
Patent number
US04045560

Reaction notes

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