Sodium hydride → HCID 21415030, compound

HRID 442528Notes

Reaction equation

HRID 442528 reaction equation
[CH2:1]([N:8]([CH2:29][CH2:30][OH:31])[C:9](=[O:28])[CH:10](Br)[CH2:11][C:12]12[CH2:26][CH:19]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][C:25]=31)[C:18]1[C:13]2=[CH:14][CH:15]=[CH:16][CH:17]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+]>C1C=CC=CC=1>[CH2:1]([N:8]1[CH2:29][CH2:30][O:31][CH:10]([CH2:11][C:12]23[CH2:26][CH:19]([C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][C:25]=42)[C:18]2[C:13]3=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:9]1=[O:28])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24758Sodium hydrideHCID 54167746HCID 54167746, compound

Product 1

HCID 21415030HCID 21415030, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of α-bromo-β(9,10-dihydro-9,10-methano-9-anthryl)propionic acid N-benzyl-N-hydroxyethylamide (1.25 g) and 65.4% sodium hydride (oily dispersion, 0.19 g) in dry benzene was stirred at room temperature for 7 hours. The reaction mixture was washed with water, dried over anhydrous sodium sulfate and evaporated to dryness to give 9-(4-benzyl-3-oxo-2-morpholinylmethyl)-9,10-dihydro-9,10-methanoanthracene, M.P. 155° - 156° C.

Workup

  1. washThe reaction mixture was washed with water
  2. dry with materialdried over anhydrous sodium sulfate
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-a305d0044f9f4fbeb0e08e636b8d10a0
Source dataset
uspto-grants-1977_08
Patent number
US04045560

Reaction notes

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