Acetic Acid → HCID 54543524, compound

HRID 442667Notes

Reaction equation

HRID 442667 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[CH:13]=[C:12]2[O:14][CH2:15][O:16][C:11]2=[CH:10][C:9]=1[CH2:17][C:18]([O:20]C)=O)=O.O.[NH2:23][NH2:24].C(O)(=O)C>C(O)C>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[C:8]2[CH:13]=[C:12]3[O:14][CH2:15][O:16][C:11]3=[CH:10][C:9]=2[CH2:17][C:18](=[O:20])[NH:24][N:23]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 24654Hydrazine hydrate (1:1)HCID 53695209HCID 53695209, compound

Product 1

HCID 54543524HCID 54543524, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared from methyl 2-(2-furoyl)-4,5-methylenedioxyphenylacetate (120 mg, 0.42 mmol), hydrazine hydrate (70 μL, 1.2 mmol), and acetic acid (50 μL) in ethanol (20 mL) as a light yellow solid (37 mg, 33%), mp: 234°-236° C. 1H NMR (CDCl3) 8.50 (s, 1H), 7.60 (m, 1H), 7.00 (s, 1H), 6.82 (s, 1H), 6.71 (m, 1H), 6.54 (m, 1H), 6.06 (s, 2H), 3.44 (s, 2H). Anal. Calcd. for C14H10N2O4 : C, 62.22; H, 3.73; N, 10.37. Found: C, 62.07; H, 3.63; N,10.11.

Sources & evidence

ORD record
ord-381985a346ab4a608d2fe1a6cd467f2f
Source dataset
uspto-grants-1999_04
Patent number
US05891871

Reaction notes

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