反应详情

In 20 ml of dry tetrahydrofuran were dissolved 1.0 g of (4R)-2-oxothiazolidine-4-carboxylic acid and 0.56 g of L-alaninol, 2.8 ml of triethylamine and 1.8 ml of diphenylphosphoryl azide were added thereto with stirring under ice-cooling, and the mixture was stirred at room temperature for 3 hours. Then, the solvent was distilled off under reduced pressure and the obtained residue was purified by silica gel column chromatography employing ethyl acetate as an eluent and further purified by silica gel column chromatography employing dichloromethane-methanol (95:5) as an eluent to obtain 0.92 g of the desired compound as colorless crystals.

1. additionwere added
2. temperaturecooling
3. stirringthe mixture was stirred at room temperature for 3 hours
4. distillationThen, the solvent was distilled off under reduced pressure
5. customthe obtained residue was purified by silica gel column chromatography
6. customfurther purified by silica gel column chromatography