Hydrochloric Acid → HCID 178510735, compound

HRID 442810Notes

Reaction equation

HRID 442810 reaction equation
[CH:1]1[C:14]2[CH:13]([CH2:15][C:16]3([C:23]4[CH:28]=[CH:27][C:26]([C:29]5[NH:33][N:32]=[N:31][N:30]=5)=[CH:25][CH:24]=4)[NH:20]C(=O)N[C:17]3=[O:22])[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[O:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[OH-:34].[Na+].Cl>>[NH2:20][C:16]([C:23]1[CH:28]=[CH:27][C:26]([C:29]2[NH:33][N:32]=[N:31][N:30]=2)=[CH:25][CH:24]=1)([CH2:15][CH:13]1[C:14]2[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=2[O:6][C:7]2[C:12]1=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:17]([OH:22])=[O:34]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178518431HCID 178518431, compound

Product 1

HCID 178510735HCID 178510735, compound

Procedure

5-(9H-xanthen-9-ylmethyl)-5-[4-(1H-tetrazol-5-yl)phenyl]hydantoin (3.2 g, 7.6 mmol) was heated with aqueous sodium hydroxide (2M, 23 ml) at 130° C. for 2 days following the procedure described in Example 1 (vi). The reaction mixture was acidified with aqueous hydrochloric acid and the product isolated by filtration to give the title compound as a white solid.

Workup

  1. customthe product isolated by filtration

Sources & evidence

ORD record
ord-8553c48d73f9439ab674eaa5bda8d563
Source dataset
uspto-grants-1999_04
Patent number
US05891899

Reaction notes

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