Ethyl Acetate → HCID 70258744, compound

HRID 442813Notes

Reaction equation

HRID 442813 reaction equation
[CH2:1]([O:8][C:9](=[O:33])[C@H:10]([CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:31]=[CH:30][C:29](F)=[CH:28][CH:27]=2)=[CH:22][CH:21]=1)[NH:11]C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:34].C(O[CH2:39][CH3:40])(=O)C.[C:41](OCC)(=O)[CH3:42]>>[ClH:34].[CH2:1]([O:8][C:9](=[O:33])[C@H:10]([CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:27]=[CH:28][C:29]3[C:30](=[CH:41][CH:42]=[CH:39][CH:40]=3)[CH:31]=2)=[CH:22][CH:21]=1)[NH2:11])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 8857Ethyl AcetateHCID 21309177HCID 21309177, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 70258744HCID 70258744, compoundYield 82%

Procedure

To a solution of N-tert.-butoxycarbonyl-4-(4-fluorophenyl)-L-phenylalanine benzyl ester (700 mg) in ethyl acetate (3.2 ml) was added 4.1N hydrogen chloride/ethyl acetate (3.8 ml). The mixture was stirred at room temperature for 17 hours. The reaction mixture was concentrated in vacuo to give 3.1 g (82%) of the titled compound (reference compound No. 1-1).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-1fa5672dd48b48a0a26adfff7ce1a674
Source dataset
uspto-grants-1999_04
Patent number
US05891912

Reaction notes

Loading…