反应详情

Compound 241 (1.0 g, 1.51 mmol) obtained in Example 242 was dissolved in a mixed solvent of tetrahydrofuran (10 ml) and ethanol (30 ml), and 20 ml of 2N hydrochloric acid was added thereto, followed by heating under reflux for 2 hours. The solvent was distilled off under reduced pressure, and a saturated aqueous solution of sodium bicarbonate was added thereto for neutralization. The mixture was stirred and the precipitated crystals were collected to give a crude product. The obtained crude product was washed with ethanol and a little amount of hexane to give 0.77 g (yield: 89%) of the title compound.

1. additionwas added
2. temperatureby heating
3. temperatureunder reflux for 2 hours
4. distillationThe solvent was distilled off under reduced pressure
5. additiona saturated aqueous solution of sodium bicarbonate was added
6. customthe precipitated crystals were collected
7. customto give a crude product
8. customThe obtained crude product
9. washwas washed with ethanol