反应详情

To a solution of benzhydryl acetate (0.77 g, 3.39 mmol) and N,N-diethylindole-2-sulfonamide (0.9 g, 3.39 mmol) in 20 ml of methylene chloride was added methanesulfonic acid (0.7 ml, 10.7 mmol), followed by stirring at room temperature for one hour. A saturated aqueous solution of sodium bicarbonate was added to the reaction solution for neutralization followed by extraction with chloroform. The resulting organic layer was washed with a saturated aqueous solution of sodium bicarbonate and a saturated aqueous solution of sodium chloride, and dried over magnesium sulfate, and the solvent was distilled off under reduced pressure to give a crude product. The obtained crude product was crystallized from diisopropyl ether to give 0.99 g (yield: 67%) of the title compound.

1. extractionfollowed by extraction with chloroform
2. washThe resulting organic layer was washed with a saturated aqueous solution of sodium bicarbonate
3. dry with materiala saturated aqueous solution of sodium chloride, and dried over magnesium sulfate
4. distillationthe solvent was distilled off under reduced pressure
5. customto give a crude product
6. customThe obtained crude product
7. customwas crystallized from diisopropyl ether