反应详情

To a solution of benzhydrol (0.58 g, 3.15 mmol) and N-isopropylindole-2-sulfonamide (0.7 g, 3.12 mmol) in 15 ml of methylene chloride was added a solution of methanesulfonic acid (0.2 ml, 3.12 mmol) in 4 ml of methylene chloride, followed by stirring at room temperature for 2.5 hours. A saturated aqueous solution of sodium bicarbonate was added to the reaction solution for neutralization and the solvent was distilled off under reduced pressure, followed by extraction with ethyl acetate. The resulting organic layer was washed with a saturated aqueous solution of sodium chloride and dried over magnesium sulfate, and the solvent was distilled off under reduced pressure to give 1.4 g of a crude product. The obtained crude product was washed with ethanol to give 1.07 g (yield: 85%) of the title compound.

1. distillationthe solvent was distilled off under reduced pressure
2. extractionfollowed by extraction with ethyl acetate
3. washThe resulting organic layer was washed with a saturated aqueous solution of sodium chloride
4. dry with materialdried over magnesium sulfate
5. distillationthe solvent was distilled off under reduced pressure
6. customto give 1.4 g of a crude product
7. customThe obtained crude product
8. washwas washed with ethanol