Hydrochloric Acid → HCID 70204754, compound

HRID 443254Notes

Reaction equation

HRID 443254 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([O:23][C:24]([F:27])([F:26])[F:25])[CH:18]=2)([CH2:14][OH:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:28]>ClCCl>[ClH:28].[F:26][C:24]([F:25])([F:27])[O:23][C:19]1[CH:18]=[C:17]([CH:22]=[CH:21][CH:20]=1)[CH2:16][C:11]1([CH2:14][OH:15])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53967867HCID 53967867, compound

Product 1

HCID 70204754HCID 70204754, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of N-tert-butoxycarbonyl-4-(3-trifluoromethoxy-benzyl)-4-hydroxymethylpiperidine (2.9 g) in dichloromethane (100 mL) at 0° C. was saturated with hydrogen chloride gas. The resultant solution was sealed with a rubber septum and stirred at room temp. for 2.5 h. The product solution was concentrated under vacuum to provide the title compound.

Workup

  1. customat 0° C.
  2. concentrationThe product solution was concentrated under vacuum

Sources & evidence

ORD record
ord-4d38f9209de24e66b0f1fd79e8f140bb
Source dataset
uspto-grants-1999_04
Patent number
US05891889

Reaction notes

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