Hydrochloric Acid → HCID 86737673, compound

HRID 443389Notes

Reaction equation

HRID 443389 reaction equation
[ClH:1].C1(C[N:6]2[CH2:24][CH2:23][C@@:13]34[C:14]5[CH:15]=[C:16]([O:21][CH3:22])[CH:17]=[CH:18][C:19]=5[CH2:20][C@@H:7]2[C@:8]3([OH:26])[CH2:9][CH2:10][C:11](=[O:25])[CH2:12]4)CC1.Cl>C(O)C>[ClH:1].[OH:26][C@:8]12[C@@H:7]3[NH:6][CH2:24][CH2:23][C@:13]1([C:14]1[CH:15]=[C:16]([O:21][CH3:22])[CH:17]=[CH:18][C:19]=1[CH2:20]3)[CH2:12][C:11](=[O:25])[CH2:10][CH2:9]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70529153HCID 70529153, compound

Product 1

HCID 86737673HCID 86737673, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A portion of Compound IV was converted to its hydrochloride salt by combining it with concentrated HCl in 10 ml of ethanol and evaporating the solvent. Toluene was added and the solution concentrated to dryness under vacuum. The residue was dissolved in a small amount of MeOH whereupon ethyl acetate was added and the solution concentrated at which point the solid was collected. This material whose structure was confirmed by mass spectral and elemental analysis was designated 179-A-19 and tested as described in Example III, infra. The other portion was left in the form of its free base and used in the experiment described in Example II.

Workup

  1. customevaporating the solvent
  2. additionToluene was added
  3. concentrationthe solution concentrated to dryness under vacuum
  4. dissolutionThe residue was dissolved in a small amount of MeOH whereupon ethyl acetate
  5. additionwas added
  6. concentrationthe solution concentrated at which point the solid
  7. customwas collected
  8. waitThe other portion was left in the form of its free base

Sources & evidence

ORD record
ord-66603f6ea71a4dfea408955aaddb52d5
Source dataset
uspto-grants-1981_04
Patent number
US04260617

Reaction notes

Loading…