Hydroxyamine hydrochloride → HCID 86737674, compound

HRID 443413Notes

Reaction equation

HRID 443413 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9](=O)[CH3:10])=[N:6][CH:7]=1.[ClH:12].[NH2:13][OH:14]>C(O)C>[ClH:12].[N:13](=[C:9]([CH3:10])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][N:6]=1)[OH:14]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 15572420HCID 15572420, compound

Product 1

HCID 86737674HCID 86737674, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The starting material is prepared as follows: The mixture of 8.64 g of 5-hydroxy-2-pyridylacetone, 4.08 g of hydroxylamine hydrochloride and 170 ml of anhydrous ethanol is refluxed for 64 hours and evaporated. The residue is taken up in the minimum amount of ethanol, the solution filtered and the filtrate evaporated, to yield the 2-(2-oximinopropyl)-5-pyridinol hydrochloride melting at 141°-145°.

Workup

  1. customThe starting material is prepared
  2. temperatureis refluxed for 64 hours
  3. customevaporated
  4. filtrationthe solution filtered
  5. customthe filtrate evaporated

Sources & evidence

ORD record
ord-2627ac006f114f9dac8ef29d6b948f2b
Source dataset
uspto-grants-1981_04
Patent number
US04260619

Reaction notes

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