Benzoyl chloride → HCID 23467138, compound

HRID 443418Notes

Reaction equation

HRID 443418 reaction equation
Cl.[NH2:2][CH:3]([CH3:12])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][N:6]=1.[C:13](Cl)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[C:22](=[O:25])(O)[O-].[Na+]>C(Cl)Cl>[C:13]([C:9]1[C:8]([OH:11])=[CH:7][N:6]=[C:5]([CH2:4][CH:3]([NH2:2])[CH3:12])[C:10]=1[C:22](=[O:25])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 7412Benzoyl chlorideHCID 516892Sodium BicarbonateHCID 23467157HCID 23467157, compound

Product 1

HCID 23467138HCID 23467138, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The starting material is prepared as follows: The mixture of 0.5 g of 2-(2-aminopropyl)-5-pyridinol hydrochloride, 0.85 g of benzoyl chloride, 10 ml of methylene chloride and 10 ml of saturated aqueous sodium bicarbonate is stirred at room temperature for 1 hour. The organic phase is separated, dried evaporated and the residue recrystallized from diethyl ether to give the dibenzoyl-2-(2-aminopropyl)-5-pyridinol melting at 110°-112°.

Workup

  1. customThe starting material is prepared
  2. customThe organic phase is separated
  3. customdried
  4. customevaporated
  5. customthe residue recrystallized from diethyl ether

Sources & evidence

ORD record
ord-b9b14f1674b04d2c8283dd06d2a21eef
Source dataset
uspto-grants-1981_04
Patent number
US04260619

Reaction notes

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