Hydrochloric Acid → HCID 23467142, compound

HRID 443422Notes

Reaction equation

HRID 443422 reaction equation
[C:1]([N:11](C)[CH:12]([CH3:21])[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][N:15]=1)(OCC1C=CC=CC=1)=O.[ClH:23]>[Pd].C(O)C>[ClH:23].[ClH:23].[CH3:1][NH:11][CH:12]([CH3:21])[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][N:15]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 23467141HCID 23467141, compound

Product 1

HCID 23467142HCID 23467142, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The mixture of 0.08 g of 2-(N-carbobenzyloxy-2-methylaminopropyl)-5-pyridinol, 5 ml of anhydrous ethanol saturated with anhydrous hydrogen chloride and 0.04 g of 10% palladium on charcoal is hydrogenated at room temperature and atmospheric pressure for 18 hours. It is filtered, the residue washed with ethanolic hydrogen chloride and the filtrate evaporated, to yield the 2-(2-methylaminopropyl)-5-pyridinol dihydrochloride, which is identical with that of Examples 15 and 16.

Workup

  1. customis hydrogenated at room temperature
  2. filtrationIt is filtered
  3. washthe residue washed with ethanolic hydrogen chloride
  4. customthe filtrate evaporated

Sources & evidence

ORD record
ord-c12034c65a8543ae83eeb6fae766a2af
Source dataset
uspto-grants-1981_04
Patent number
US04260619

Reaction notes

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