Chlorosuccinimide → L-Valine, N-[2-chloro-4-(trifluoromethyl)phenyl]-

HRID 443466Notes

Reaction equation

HRID 443466 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C@@H:10]([CH:14]([CH3:16])[CH3:15])[C:11]([OH:13])=[O:12])=[CH:5][CH:4]=1.[Cl:19]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Cl:19][C:7]1[CH:8]=[C:3]([C:2]([F:17])([F:18])[F:1])[CH:4]=[CH:5][C:6]=1[NH:9][C@@H:10]([CH:14]([CH3:16])[CH3:15])[C:11]([OH:13])=[O:12]

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 13388454Valine, N-[4-(trifluoromethyl)phenyl]-

Product 1

HCID 156536L-Valine, N-[2-chloro-4-(trifluoromethyl)phenyl]-

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

Following the method of Example 6, (S)-2-(4-trifluoromethylphenylamino)-3-methylbutanoic acid and N-chlorosuccinimide in carbon tetrachloride are reacted, yielding (S)-2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoic acid.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-538744adec3f416388c8076db8a981d7
Source dataset
uspto-grants-1981_04
Patent number
US04260633

Reaction notes

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