2,2,2-Trifluoroethanol → HCID 57181364, compound

HRID 443714Notes

Reaction equation

HRID 443714 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]2[C:13]([C:14](Cl)=[O:15])=[CH:12][S:11][N:10]=2)[CH:4]=1.[F:19][C:20]([F:24])([F:23])[CH2:21][OH:22]>>[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]2[C:13]([C:14]([O:22][CH2:21][C:20]([F:24])([F:23])[F:19])=[O:15])=[CH:12][S:11][N:10]=2)[CH:4]=1

Participants

3

Reactant 2

HCID 64092,2,2-TrifluoroethanolHCID 23465058HCID 23465058, compound

Product 1

HCID 57181364HCID 57181364, compoundYield 88%

Procedure

A solution of 2.50 g (0.00856 mol) of 3-(α,α,α-trifluoro-m-tolyl)-4-isothiazolecarbonyl chloride and 50 ml of 2,2,2-trifluoroethanol was held at reflux for 40 minutes, was allowed to stand overnight, and was concentrated under vacuum (to 90° at 0.1 torr) to give 2.68 g (88%) of oil, nD24 =1.4976.

Workup

  1. temperatureat reflux for 40 minutes
  2. concentrationwas concentrated under vacuum (to 90° at 0.1 torr)

Sources & evidence

ORD record
ord-52724075375649558785b874269f43d7
Source dataset
uspto-grants-1981_04
Patent number
US04261728

Reaction notes

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