Trichloroethanol → HCID 57215698, compound

HRID 443715Notes

Reaction equation

HRID 443715 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]2[C:13]([C:14](Cl)=[O:15])=[CH:12][S:11][N:10]=2)[CH:4]=1.[Cl:19][C:20]([Cl:24])([Cl:23])[CH2:21][OH:22]>>[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]2[C:13]([C:14]([O:22][CH2:21][C:20]([Cl:24])([Cl:23])[Cl:19])=[O:15])=[CH:12][S:11][N:10]=2)[CH:4]=1

Participants

3

Reactant 2

HCID 8259TrichloroethanolHCID 23465058HCID 23465058, compound

Product 1

HCID 57215698HCID 57215698, compound

Procedure

A solution of 2.0 g (0.0069 mol) of 3-(α,α,α-trifluoro-m-tolyl-4-isothiazolecarbonyl chloride and 1.22 g (1.18 equivalents) of 2,2,2-trichloroethanol was heated at 70°-140° in an oil bath for 6.5 hours. The reaction mixture was concentrated under vacuum to give 1.78 g of oil, nD23 =1.5499 (yield 63.8%).

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-1982bec6e74a4458bf5c2ea8b6d7159e
Source dataset
uspto-grants-1981_04
Patent number
US04261728

Reaction notes

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