Potassium Carbonate → HCID 20514569, compound

HRID 443887Notes

Reaction equation

HRID 443887 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[NH:11][C:12]([NH:14][CH:15]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:16][OH:17])=[S:13].C(=O)([O-])[O-].[K+].[K+].CN(C)C(=O)C>O>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]2[S:13][C:12]([NH:14][CH:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:16][OH:17])=[N:11][C:3]=2[CH:4]=1)([O-:10])=[O:9]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 31374DimethylacetamideHCID 20514579HCID 20514579, compound

Product 1

HCID 20514569HCID 20514569, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 116 parts of N-(2-chloro-5-nitrophenyl)-N'-(2-hydroxy-1-phenylethyl)thiourea, 50 parts of potassium carbonate and 675 parts of N,N-dimethylacetamide is stirred and refluxed for 1 hour. The reaction mixture is poured onto 2000 parts of water. After cooling, the whole is filtered over Hyflo and the product is allowed to crystallize from the filtrate. It is filtered off and dried, yielding 23 parts of β-(5-nitro-2-benzothiazolylamino)benzeneethanol.

Workup

  1. temperaturerefluxed for 1 hour
  2. temperatureAfter cooling
  3. filtrationthe whole is filtered over Hyflo
  4. customto crystallize from the filtrate
  5. filtrationIt is filtered off
  6. customdried

Sources & evidence

ORD record
ord-8158cd082f054144a657f2185468ae77
Source dataset
uspto-grants-1981_04
Patent number
US04262004

Reaction notes

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