1,8-Diazabicyclo(5.4.0)undec-7-ene → Acetophenone

HRID 444029Notes

Reaction equation

HRID 444029 reaction equation
[C:1]([CH2:9]C(O)=O)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1CCN2C(=NCCC2)CC1>>[CH3:9][C:1]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:8]

Participants

3

Reactant 2

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 97045Benzoylacetic acid

Product 1

HCID 7410AcetophenoneYield 100%

Procedure

When reacting 10 mmol of benzoylacetic acid with 20 mmol DBU at 25° C. for 3 hrs., phenyl methyl ketone was obtained in a yield of 100% of theory.

Workup

  1. customat 25° C.
  2. customfor 3 hrs

Sources & evidence

ORD record
ord-8cf3c3dcf3114d5f9012237bdc08c5cf
Source dataset
uspto-grants-1981_04
Patent number
US04262157

Reaction notes

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