Sodium hydride → HCID 13133040, compound

HRID 444206Notes

Reaction equation

HRID 444206 reaction equation
[CH3:1][N:2]1[C:10]2[NH:11][C:12](=[O:19])[C:13]3[C:18]([C:9]=2[C:8]2[CH:7]=[C:6]([Cl:20])[CH:5]=[CH:4][C:3]1=2)=[CH:17][CH:16]=[CH:15][CH:14]=3.[H-].[Na+].[CH:23]1([CH2:26]Br)[CH2:25][CH2:24]1>>[CH:23]1([CH2:26][O:19][C:12]2[C:13]3[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:9]3[C:8]4[CH:7]=[C:6]([Cl:20])[CH:5]=[CH:4][C:3]=4[N:2]([CH3:1])[C:10]=3[N:11]=2)[CH2:25][CH2:24]1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 81503BromomethylcyclopropaneHCID 13133047HCID 13133047, compound

Product 1

HCID 13133040HCID 13133040, compound

Procedure

5-Cyclopropylmethyloxy-7-methyl-10-chloro-7H-indolo(2,3-c)isoquinoline (melting point 141°-142° C.) is prepared from 7-methyl-10-chloro-7H-indolo(2,3-c)isoquinolin-5(6H)-one, sodium hydride and cyclopropylmethyl bromide by the method described in Example 8.

Sources & evidence

ORD record
ord-0c607437d1164ee587091939ebfa518c
Source dataset
uspto-grants-1981_04
Patent number
US04263304

Reaction notes

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