Sodium hydride → HCID 13133041, compound

HRID 444207Notes

Reaction equation

HRID 444207 reaction equation
[CH3:1][N:2]1[C:10]2[NH:11][C:12](=[O:19])[C:13]3[C:18]([C:9]=2[C:8]2[CH:7]=[C:6]([Cl:20])[CH:5]=[CH:4][C:3]1=2)=[CH:17][CH:16]=[CH:15][CH:14]=3.[H-].[Na+].[CH2:23]([O:25][CH2:26][CH2:27]Br)[CH3:24]>>[CH3:24][CH2:23][O:25][CH2:26][CH2:27][O:19][C:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]2[C:8]3[CH:7]=[C:6]([Cl:20])[CH:5]=[CH:4][C:3]=3[N:2]([CH3:1])[C:10]=2[N:11]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 611412-Bromoethyl ethyl etherHCID 13133047HCID 13133047, compound

Product 1

HCID 13133041HCID 13133041, compound

Procedure

5-β-Ethoxyethyloxy-7-methyl-10-chloro-7H-indolo(2,3-c)isoquinoline (melting point 93.5°-95.5° C.) is prepared from 7-methyl-10-chloro-7H-indolo(2,3-c)isoquinolin-5(6H)-one, sodium hydride and β-ethoxyethyl bromide by the method described in Example 8.

Sources & evidence

ORD record
ord-3ae8a202adb449c2ac492ac9edded60d
Source dataset
uspto-grants-1981_04
Patent number
US04263304

Reaction notes

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