反应详情

To a solution of 3-isopropylphenyl methylcarbamate (3.8 g, 0.02 mol) in 20 ml anhydrous tetrahydrofuran was added 2.0 g pyridine (0.025 mol) and 2.5 g thionyl chloride (0.021 mol). The mixture was stirred for 12 hours at room temperature. Pyridine (2 g, 0.025 mol) was added and followed by 2.5 g of 1-hexanol (0.025 mol) added dropwise. Workup and purification according to procedure described for other derivatives yielded 6.5 g of the desired product (95% yield).

1. additionadded dropwise
2. customWorkup and purification