反应详情

A mixture of N-tert-butoxycarbonyl-2-(4-hydroxyphenyl)glycine phenacyl ester prepared as above (3.56 g.), phenacyl bromide (1.84 g.) and potassium carbonate (1.28 g.) in an anhydrous acetone (71 ml.) was heated to reflux for 7 hours. The insoluble substances were filtered off and the filtrate was evaporated to dryness under reduced pressure. The residual oil was dissolved in chloroform, washed with water, dried over magnesium sulfate, and evaporated to dryness under reduced pressure. The residue was triturated with diisopropyl ether to give crystalline N-tert-butoxycarbonyl-2-(4-phenacyloxyphenyl)glycine phenacyl ester (4.12 g.), which was recrystallized from ethanol to give the pure material, mp 125° to 126.5° C.

1. temperaturewas heated
2. temperatureto reflux for 7 hours
3. filtrationThe insoluble substances were filtered off
4. customthe filtrate was evaporated to dryness under reduced pressure
5. dissolutionThe residual oil was dissolved in chloroform
6. washwashed with water
7. dry with materialdried over magnesium sulfate
8. customevaporated to dryness under reduced pressure
9. customThe residue was triturated with diisopropyl ether