反应详情

To a solution of N-tert-butoxycarbonyl-2-(4-phenacyloxyphenyl)glycin phenacyl ester (1.0 g.) in ethyl acetate (10 ml.) was added a mixture of hydrobromic acid and acetic acid (2 ml., 4:1 v/v), and then the mixture was stirred for half an hour at ambient temperature. The precipitates were collected by filtration and washed with ethyl acetate to give 2-(4-phenacyloxyphenyl)glycine phenacyl ester hydrobromide (830 mg.), which was recrystallized from a mixture of ethanol, methanol and diethyl ether to give the pure crystals (550 mg.), mp 176° to 177° C.

1. filtrationThe precipitates were collected by filtration
2. washwashed with ethyl acetate