1-(Piperidin-4-yl)imidazolidin-2-one → HCID 23463820, compound

HRID 444451Notes

Reaction equation

HRID 444451 reaction equation
[CH2:1]([O:8][C:9]1[C:14]([O:15][CH2:16][CH:17]2[O:19][CH2:18]2)=[CH:13][CH:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:20]1[CH2:25][CH2:24][CH:23]([N:26]2[CH2:30][CH2:29][NH:28][C:27]2=[O:31])[CH2:22][CH2:21]1>C(O)(C)C>[OH:19][CH:17]([CH2:16][O:15][C:14]1[C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[N:10][CH:11]=[CH:12][CH:13]=1)[CH2:18][N:20]1[CH2:21][CH2:22][CH:23]([N:26]2[CH2:30][CH2:29][NH:28][C:27]2=[O:31])[CH2:24][CH2:25]1

Participants

4

Reactant 2

HCID 130317571-(Piperidin-4-yl)imidazolidin-2-oneHCID 234638152-Benzyloxy-3-(2,3-epoxypropoxy)-pyridine

Product 1

HCID 23463820HCID 23463820, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

4.8 g of 2-benzyloxy-3-(2,3-epoxypropoxy)-pyridine and 3.0 g of 1-(4-piperidyl)-imidazolidin-2-one are dissolved in 50 ml of isopropanol and the solution is stirred for 15-18 hours at 20-30°. The crystals which have precipitated out are filtered off with suction and washed with ether and yield 1-{1-[2-hydroxy-3-(2-benzyloxy-3-pyridyloxy)-propyl]-4-piperidyl}-imidazolidin-2-one with a melting point of 145°-147°.

Workup

  1. customThe crystals which have precipitated out
  2. filtrationare filtered off with suction
  3. washwashed with ether

Sources & evidence

ORD record
ord-305f614cadc94191a628ec743c5b8a9b
Source dataset
uspto-grants-1981_04
Patent number
US04264599

Reaction notes

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