反应详情

6-Chloro-3-nitropyridine (4.0 grams) and 4-chlorothiophenol (3.7 grams) were mixed in 100 ml. of dry DMF and lithium hydroxide (1.2 grams) added portionwise. After the reaction mixture had stirred for about 5 minutes, it darkened and became warm. It was allowed to stir with a drying tube for 4 hours, poured over ice water and the product separated by filtration. It was crystallized from ethyl acetate-ethanol, yield: 5.0 grams, m.p. 134°-136° C.

1. temperaturebecame warm
2. stirringto stir with a drying tube for 4 hours
3. customthe product separated by filtration
4. customIt was crystallized from ethyl acetate-ethanol, yield: 5.0 grams, m.p. 134°-136° C.