6-[(4-chlorophenyl)sulfanyl]-3-pyridinylamine → HCID 23463873, compound

HRID 444466Notes

Reaction equation

HRID 444466 reaction equation
[CH3:1][O:2][C:3]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[C:4]=1[C:5]([N:7]=[C:8]=[O:9])=[O:6].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([S:23][C:24]2[N:29]=[CH:28][C:27]([NH2:30])=[CH:26][CH:25]=2)=[CH:19][CH:18]=1>C(OCC)(=O)C>[CH3:15][O:14][C:10]1[CH:11]=[CH:12][CH:13]=[C:3]([O:2][CH3:1])[C:4]=1[C:5]([NH:7][C:8]([NH:30][C:27]1[CH:28]=[N:29][C:24]([S:23][C:20]2[CH:21]=[CH:22][C:17]([Cl:16])=[CH:18][CH:19]=2)=[CH:25][CH:26]=1)=[O:9])=[O:6]

Participants

4

Reactant 2

HCID 28001276-[(4-chlorophenyl)sulfanyl]-3-pyridinylamineHCID 133219942,6-Dimethoxybenzoyl isocyanate

Product 1

HCID 23463873HCID 23463873, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2,6-Dimethoxybenzoyl isocyanate (2.07 grams; 0.01 mole) and 6-(4-chlorophenylthio)-3-aminopyridine (2.37 grams; 0.01 mole) were mixed in 100 ml. of ethyl acetate and stirred at room temperature for 3 hours. Solvent was removed in vacuo and the product crystallized from hexanes-ethyl acetate, yield 0.6 gram, m.p. 172°-174° C.

Workup

  1. customSolvent was removed in vacuo
  2. customthe product crystallized from hexanes-ethyl acetate, yield 0.6 gram, m.p. 172°-174° C.

Sources & evidence

ORD record
ord-7f49af575b59405b9e2cb451162de747
Source dataset
uspto-grants-1981_04
Patent number
US04264605

Reaction notes

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