反应详情

5 g (12.55 mmol) of ethyl 6-(2,4-dichlorophenyl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate (Example 11A) were dissolved in 700 ml of THF, and 952 mg (25.1 mmol) of lithium aluminum hydride were added at RT. The mixture was stirred at RT for 2 h, after complete conversion methanol was added first, and the pH was then adjusted to 6 using dilute hydrochloric acid. The mixture was extracted repeatedly with ethyl acetate. Removal of the solvent gave 3.12 g (80% of theory) of the product as a solid.

1. extractionThe mixture was extracted repeatedly with ethyl acetate
2. customRemoval of the solvent