反应详情

Tert-butyl 3-aminopropanoate hydrochloride (5 g, 27.7 mmol) was dissolved in methanol (150 mL). Diisopropylethylamin (4.73 mL, 27.7 mmol) was added followed by 4-carboxybenzaldehyd. The mixture is heated to reflux for 1 hour. After cooling to room temperature sodium cyanoborohydride (1.77 g, 22.1 mmol) was added under nitrogen and stirred for 1 hour at room temperature. Acetic acid (15 mL) was added and the mixture was stirred for an additional 1 hour. The mixture was poured into water (300 mL) and stirred at room temperature over night. The water solution was washed with ethyl acetate (3×250 mL). The organic phase dried (Na2SO4) and solvent removed in vacuo to yield the crude product as an oil which solidifies by standing. The crude product was used in the next step without further purification.

1. temperatureThe mixture is heated
2. temperatureto reflux for 1 hour
3. additionwas added under nitrogen
4. stirringthe mixture was stirred for an additional 1 hour
5. stirringstirred at room temperature over night
6. washThe water solution was washed with ethyl acetate (3×250 mL)
7. dry with materialThe organic phase dried (Na2SO4) and solvent
8. customremoved in vacuo