反应详情

3-bromophenol (0.50 g) was dissolved in acetone, and to the resultant solution, potassium carbonate (1.49 g), potassium iodide (14 mg), and 4-bromomethylphenyl boronic acid (0.62 g) were added, followed by heating the resultant reaction mixture under reflux for 3 hours. The reaction mixture was left to be cooled down, and to the reaction mixture, water was added, and a 2M hydrochloric acid was added to adjust pH of the reaction mixture to 2 to 3, followed by extracting the reaction mixture with ethyl acetate. The organic phase was washed with saturated saline and was dried over anhydrous sodium sulfate. From the organic phase, the solvent was distilled off under reduced pressure, and the resultant residue was purified by silica gel column chromatography to obtain the subject compound (0.45 g) as a colorless solid.

1. temperatureby heating the resultant
2. customreaction mixture
3. temperatureunder reflux for 3 hours
4. waitThe reaction mixture was left
5. temperatureto be cooled down
6. extractionby extracting the reaction mixture with ethyl acetate
7. washThe organic phase was washed with saturated saline
8. dry with materialwas dried over anhydrous sodium sulfate
9. distillationFrom the organic phase, the solvent was distilled off under reduced pressure
10. customthe resultant residue was purified by silica gel column chromatography