Hydrochloric Acid → HCID 67307357, compound

HRID 445212Notes

Reaction equation

HRID 445212 reaction equation
[ClH:1].CCOCC.[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[C:15]([O:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][N:29]3[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]3)=[CH:22][CH:21]=1)=[C:14]([C:35]1[C:36]([C:40]#[N:41])=[CH:37][S:38][CH:39]=1)[CH:13]=[CH:12]2>ClCCl>[ClH:1].[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[C:15]([O:19][C:20]1[CH:21]=[CH:22][C:23]([O:26][CH2:27][CH2:28][N:29]3[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]3)=[CH:24][CH:25]=1)=[C:14]([C:35]1[C:36]([C:40]#[N:41])=[CH:37][S:38][CH:39]=1)[CH:13]=[CH:12]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 58338572HCID 58338572, compound

Product 1

HCID 67307357HCID 67307357, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Add a solution of Hydrogen Chloride in ether (1 M, 180 μL, 180.0 μmol) to a prepared solution of 4-(6-methoxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl)thiophene-3-carbonitrile (87 mg, 179.5 μmol) in Dichloromethane (2 mL). Stir the mixture for 10 min. Concentrate the mixture to obtain the title compound (95 mg, 179 μmol).

Workup

  1. concentrationConcentrate the mixture

Sources & evidence

ORD record
ord-9802a598567e4531b4aea992a811f9b2
Source dataset
uspto-grants-2013_07
Patent number
US08476300B2

Reaction notes

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