HRID445224

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID3283

Diethyl Ether

C4H10O

结构：COc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(-c3csc(S(C)(=O)=O)c3)ccc2c1

HCID58338561

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2c(Oc3ccc(OCCN4CCCCC4)cc3)c(-c3csc(S(C)(=O)=O)c3)ccc2c1.Cl

HCID67308285

未命名化合物

收率 100%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Dissolve 1-[2-[4-[[6-methoxy-2-(5-methylsulfonyl-3-thienyl)-1-naphthyl]oxy]phenoxy]ethyl]piperidine (0.3 g, 0.55 mmol) in ethyl acetate. Add ether (10 mL) and cool to 0° C. Add hydrochloric acid (2M in ether, 0.4 mL, 0.84 mmol) and collect the resulting precipitate by filtration. Dissolve the solids in ethylacetate and concentrate to obtain 1-[2-[4-[[6-methoxy-2-(5-methylsulfonyl-3-thienyl)-1-naphthyl]oxy]phenoxy]ethyl]piperidine hydrochloride (0.35 g, 0.55 mmol).

WORKUP

后处理

filtrationby filtration
dissolutionDissolve the solids in ethylacetate
concentrationconcentrate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fcc98be126db41db80f6317a9c69075b
来源数据集: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08476300B2
来源说明: uspto-grants-2013_07

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9]([O:13][C:14]1[CH:28]=[CH:27][C:17]([O:18][CH2:19][CH2:20][N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:16][CH:15]=1)=[C:8]([C:29]1[CH:33]=[C:32]([S:34]([CH3:37])(=[O:36])=[O:35])[S:31][CH:30]=1)[CH:7]=[CH:6]2.CCOCC.[ClH:43]>C(OCC)(=O)C>[ClH:43].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9]([O:13][C:14]1[CH:15]=[CH:16][C:17]([O:18][CH2:19][CH2:20][N:21]3[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]3)=[CH:27][CH:28]=1)=[C:8]([C:29]1[CH:33]=[C:32]([S:34]([CH3:37])(=[O:36])=[O:35])[S:31][CH:30]=1)[CH:7]=[CH:6]2