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HRID445234

反应详情

EQUATION

反应方程式

HRID 445234 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：O=C([O-])[O-].[Na+].[Na+]
HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

结构：CCOC(OCC)c1ccc(CN(Cc2nccn2S(=O)(=O)N(C)C)Cc2nccn2S(=O)(=O)N(C)C)cc1
HCID67284731

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)S(=O)(=O)n1ccnc1CN(Cc1ccc(C=O)cc1)Cc1nccn1S(=O)(=O)N(C)C
HCID86664464

1H-Imidazole-1-sulfonamide, 2,2′-[[[(4-formylphenyl)methyl]imino]bis(methylene)]bis[N,N-dimethyl-

C20H27N7O5S2

收率 85.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

2,2′-[{[4-(diethoxymethyl)benzyl]imino}bis(methylene)]bis(N,N-dimethyl-1H-imidazole-1-sulfonamide) (International Publication WO 2007/058322 pamphlet, Example 27; 10.0 g), ethyl acetate (100 mL) and 2N hydrochloric acid (100 mL) were added, followed by stirring at room temperature for 3 minutes. The aqueous layer was neutralized with an aqueous saturated sodium carbonate solution, extracted with ethyl acetate and then washed with saturated brine. The organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure to obtain the title compound (7.46 g) having the following physical properties.

WORKUP

后处理

  1. extractionextracted with ethyl acetate
  2. washwashed with saturated brine
  3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  4. concentrationconcentrated under reduced pressure