反应详情

3-Methyl-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline (0.100 g, 0.343 mmol, semi-pure from the previous reaction) was dissolved in 3 mL DCM and DIEA (0.119 mL, 0.687 mmol) and 3-isocyanatopyridine (79 mg, 0.659 mmol) were added. Stirring was continued for 2 h and the mixture was hydrolyzed with 3 drops of water, diluted with 3 mL DMF and injected on the HPLC for purification. The title compound was obtained. No stereochemical assignment was performed.

1. custominjected on the HPLC for purification