Hydrochloric Acid → Methyl 2-hydroxy-8-phenyloctanimidate

HRID 445392Notes

Reaction equation

HRID 445392 reaction equation
[OH:1][CH:2]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:3]#[N:4].Cl.[CH3:18][OH:19]>>[OH:1][CH:2]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:3](=[NH:4])[O:19][CH3:18]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 539253882-Hydroxy-8-phenyloctanenitrile

Product 1

HCID 66822535Methyl 2-hydroxy-8-phenyloctanimidate

Procedure

A solution of 2-hydroxy-8-phenyloctanenitrile (5 g) in methanol (50 mL) was cooled to −78° C. and a stream of HCl (g) was introduced for 4 min. The mixture was stored at −10° C. for 15 h, then concentrated to yield methyl 2-hydroxy-8-phenyloctanimidate. (MH+=286).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-04d509292190443fbfc8a13bfa4d535f
Source dataset
uspto-grants-2013_07
Patent number
US08476302B2

Reaction notes

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