Hydrochloric Acid → HCID 58797614, compound

HRID 446194Notes

Reaction equation

HRID 446194 reaction equation
Cl.[P:2]([O:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17][O:18][Si](C(C)(C)C)(C)C)=[CH:13][CH:12]=1)([O:7][CH2:8][CH3:9])([O:4][CH2:5][CH3:6])=[O:3].C(=O)(O)[O-].[Na+]>C(O)C>[P:2]([O:10][C:11]1[CH:12]=[CH:13][C:14]([CH2:17][OH:18])=[CH:15][CH:16]=1)([O:7][CH2:8][CH3:9])([O:4][CH2:5][CH3:6])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 59859472HCID 59859472, compound

Product 1

HCID 58797614HCID 58797614, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The solution of HCl (8 ml) in ethanol (100 ml) was added to diethyl 4-(TBDMS-oxymethyl)phenyl phosphate. The resultant solution was stirred for 20 minutes and neutralized with sodium bicarbonate. The mixture was extracted three times with ether and the combined organic layer was dried over magnesium sulfate. After removal of solvent, the compound was obtained in a yield of 98%. Without further purification, it was directly used in next step.

Workup

  1. extractionThe mixture was extracted three times with ether
  2. dry with materialthe combined organic layer was dried over magnesium sulfate
  3. customAfter removal of solvent
  4. customthe compound was obtained in a yield of 98%
  5. customWithout further purification, it

Sources & evidence

ORD record
ord-3c3afdf507b3486db0dea263bb11896a
Source dataset
uspto-grants-2013_07
Patent number
US08476450B2

Reaction notes

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