反应详情

温度

60 °C

0.63 g (1.80 mmol) of ethyl 8-anilino-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate were dissolved in 100 mL of a mixture tetrahydrofuran/methanol/water 8/1/1 and 0.19 g (4.53 mmol) of lithium hydroxide hydrate were added. The solution was stirred at 60° C. for 1.5 hours. The mixture was then cooled to room temperature and 1N HCl added until neutral pH. Water was added and the resulting precipitate collected by filtration (87% yield).

1. additionwere added
2. temperatureThe mixture was then cooled to room temperature
3. filtrationthe resulting precipitate collected by filtration (87% yield)